Best Proofpoint Advanced Threat Protection Alternatives ranked by AI · updated Aug 2026

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Proofpoint Advanced Threat Protection is an enterprise email-security service that detects and blocks phishing, malware, ransomware, and other targeted attacks. It is designed for organizations needing layered analysis, URL protection, attachment sandboxing, and post-delivery remediation.

Developer: Proofpoint Price: N/A 🎯 proofpoint.com/us/products/advanced-threat-protection

🔒 Email Security Cloud Security Anti-Phishing enterprise security threat detection

Top 6 Proofpoint Advanced Threat Protection alternatives

Microsoft Defender for Office 365

Microsoft

💡 Pick it if your organization already runs Microsoft 365 and wants tightly integrated email protection.

Microsoft Defender for Office 365 is a cloud email security service for Microsoft 365 organizations. It adds anti-spam, anti-malware, phishing protection, Safe...

Pros

Deep integration with Exchange Online, Outlook, and Microsoft 365 administration
Includes strong phishing investigation and automated response features
Usually more cost-effective for organizations already licensed for Microsoft 365

Cons

Less suitable for organizations not using Microsoft 365
Administration is more complex than dedicated gateway filters
Some advanced protections require higher-priced plans

From $2/user/mo

Alternatives to Microsoft Defender... → Visit site

Mimecast Email Security

💡 Pick it if you want email protection combined with continuity, archiving, and broader email-management features.

Mimecast Email Security offers email protection against advanced threats, spam, and data leaks, with continuity features for email availability.

Pros

Robust threat protection
Email continuity features

Cons

Complex setup process for some users

Contact for pricing

Alternatives to Mimecast Email Sec... →

Abnormal Security

💡 Pick it if behavioral detection of business email compromise matters more than traditional gateway controls.

Abnormal Security is a cloud email security platform for organizations that need protection from business email compromise, account takeover, and sophisticated social...

Pros

Excellent behavioral detection for highly targeted BEC attacks
Usually requires less rule maintenance than signature-heavy gateways
Covers account takeover and other human-layer threats

Cons

Quote-based pricing can be costly for smaller teams
Less focused than Proofpoint on traditional secure email gateway controls
Behavioral models may need tuning in unusual communication environments

N/A

Alternatives to Abnormal Security → Visit site

Cisco Secure Email

Cisco

💡 Pick it if you need flexible hybrid deployment and already use Cisco security infrastructure.

Cisco Secure Email is an enterprise email security service for blocking spam, malware, phishing, and data-exfiltration attempts. It combines reputation filtering, advanced...

Pros

Strong integration with Cisco security and networking ecosystems
Mature filtering for spam, malware, and malicious attachments
Supports detailed policy, encryption, and data-loss controls

Cons

Can require more specialized administration than cloud-native competitors
User experience is less streamlined than Microsoft-native protection
Advanced configuration may be excessive for smaller teams

Contact sales

Alternatives to Cisco Secure Email → Visit site

Barracuda Email Protection

Barracuda Networks

💡 Pick it if you want solid email protection plus continuity and backup in a broader mid-market suite.

Barracuda Email Protection is a cloud service for filtering spam, malware, phishing, and impersonation threats in business email. It also provides email...

Pros

Combines gateway filtering with continuity and archiving options
Supports Microsoft 365, Google Workspace, and other mail environments
Provides approachable administration for many SMB and mid-market teams

Cons

Advanced features are split across product packages
Threat investigation is less unified than Microsoft-native protection
Pricing generally requires a reseller or sales quote

Quote-based

Alternatives to Barracuda Email Pr... → Visit site

Check Point Harmony Email & Collaboration

Check Point Software Technologies

💡 Pick it if you need one service for email and collaboration-app protection within a Check Point security stack.

Check Point Harmony Email & Collaboration protects Microsoft 365 and other cloud collaboration environments from phishing, malware, account takeover, and malicious file...